Terminal: Where is the shell start-up file?
You’re probably using bash so just add these 3 lines to ~/.bash_profile: $ cat >> ~/.bash_profile export WORKON_HOME=$HOME/.virtualenvs export PROJECT_HOME=$HOME/directory-you-do-development-in source /usr/local/bin/virtualenvwrapper.sh ^D where ^D means you type Control+D (EOF). Then either close your terminal window and open a new one, or you can “reload” your .bash_profile like this: $ source ~/.bash_profile