Change Permissions on Registry key via Command line

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There is an excellent rundown of how to do it in PowerShell here.

Essentially, you can use Get-Acl and Set-Acl in PowerShell like you would for any other path.

$acl = Get-Acl HKLM:\SOFTWARE\stuff
$rule = New-Object System.Security.AccessControl.RegistryAccessRule ("Domain\user","FullControl","Allow")
$acl.SetAccessRule($rule)
$acl |Set-Acl -Path HKLM:\SOFTWARE\stuff

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