You can open the preferences (multiple options):
- keyboard shortcut Ctrl + Alt + Shift + P
Tools
-> Preferences
And depending on the Spyder version you can change the interpreter in the Python interpreter
section (Spyder 3.x):
![enter image description here](https://i.stack.imgur.com/0O9g6.png)
or in the advanced Console
section (Spyder 2.x):
![enter image description here](https://i.stack.imgur.com/4QHnj.png)