IIS Manager can’t configure .NET Compilation on .NET 4 Applications

Ok, i’ve got it.

The Problem is, that my systems a 64 Bit systems and the aspnet_regiis i’ve called was the 32 Bit Version. After calling aspnet_regiis from the Framework64 Directory everything was fine.

Thanks to Scott Hanselman http://www.hanselman.com/blog/ASPNET4BreakingChangesAndStuffToBeAwareOf.aspx

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