If you have a list of columns you can just select those:
In [11]: df
Out[11]:
1 2 3 4 5 6
A x x x x x x
B x x x x x x
C x x x x x x
In [12]: col_list = [3, 5]
In [13]: df = df[col_list]
In [14]: df
Out[14]:
3 5
A x x
B x x
C x x